Multiple myeloma is a relatively rare form of cancer according to the American Cancer Society. The disease is expected to impact the lives of nearly 19, 000 men and about 14,000 women in 2019. Even more distressing, roughly 13,000 individuals will lose their lives to myeloma. Multiple Myeloma is a form of blood cancer that is typically linked to lymphoma and leukemia. In this article, we will take a closer look at the symptoms and stage of multiple myeloma as well as some of the treatments currently available. ??
Multiple myeloma is a relatively rare form of cancer according to the American Cancer Society. The disease is expected to impact the lives of nearly 19, 000 men and about 14,000 women in 2019. Even more distressing, roughly 13,000 individuals will lose their lives to myeloma. Multiple Myeloma is a form of blood cancer that is typically linked to lymphoma and leukemia. In this article, we will take a closer look at the symptoms and stage of multiple myeloma as well as some of the treatments currently available.
Multiple myeloma generally occurs when plasma cells begin to multiply out of control, which, in turn, leads to too much immunoglobulin in both the bones and blood. Like other forms of cancer, it is not immediately clear what precipitates this chain of events or what causes the disease in the first place. Nonetheless, this buildup of immunoglobulin is not limited to bone and blood only; it can build up throughout the body to the point where it can cause organ damage. It is also not uncommon for immunoglobulin to start crowding healthy blood cells in the bones, which can weaken and ultimately dissolve the bone tissue. As myeloma progresses, one's health can quickly begin to deteriorate. Studies show that the excess plasma that collects in the bone marrow will ultimately leak out and begin to spread throughout the body, which can potentially damage vital organs.
Common risk factors for developing multiple myeloma include:
It is also important to note that African-Americans are at a greater risk of developing multiple myeloma when compared to their Caucasian counterparts. Additionally, those who have been diagnosed with other plasma cell diseases like systemic light-chain AL amyloidosis and monoclonal immunoglobulin deposition disease, for example, are likely to develop multiple myeloma as well.
In its earliest stages, multiple myeloma is generally asymptomatic; however, as the disease advances, most people will experience the following:
Additional symptoms associated with multiple myeloma may include
If an individual is experiencing any of these symptoms, they should be seen by a physician who can order a blood test to confirm the presence of the disease.
The most commonly ordered blood tests include:
In addition to blood tests, a urine test and a bone marrow biopsy may be needed to confirm that a patient has developed multiple myeloma. These blood and urine tests will enable physicians to determine the type of abnormal proteins the patient's body is producing and whether or not they are linked to the disease.
The bone marrow biopsy, which often entails inserting a needle into the patient's hip to collect a sample of bone tissue marrow, is used to reveal how many plasma cells are inside of the patient's bone tissue. Of course, the testing does not stop here. To definitively diagnose a patient with multiple myeloma, CT scans, MRIs, PET scans, and X-rays may also be required as well.
In treating multiple myeloma, most physicians will take into consideration the symptoms that a patient is experiencing before deciding on a specific course of treatment.
For example, if a patient has multiple myeloma but is otherwise asymptomatic, most physicians will choose to monitor the patient as opposed to starting them on a particular treatment right away. However, if a patient is experiencing symptoms, most physicians will work with the patient to create a treatment plan that not only addresses their symptoms but also helps improve their overall health.
In some cases, physicians may encourage their patients to work with a nutritionist to develop healthier eating habits. Depending on the severity of their symptoms and how far the disease has progressed, some physicians may advise patients to take part in clinical trials. In doing so, patients can take advantage of new medications and combinations that can help them better manage their multiple myeloma symptoms.
It is important to note that chemotherapy drugs are often combined to yield the best possible results when it comes to treating multiple myeloma.
Targeted therapies involve the use of specific medications that work to target genes, proteins, and tissues in the body to help prevent or minimize the growth of cancer cells. Some of the most common targeted therapies include:
Immunomodulatory drugs – These medications are designed to boost the immune system and also prevent new blood vessels from forming in the bone marrow, which deprives multiple myeloma cells of the nourishment that they need to survive.
Monoclonal antibody therapy - These cancer treatment drugs are designed to boost the immune system, increasing its ability to spot myeloma cells and destroy them.
Monoclonal antibody drugs are generally prescribed to patients who are asymptomatic as a means of preventing myeloma from progressing to the point where additional treatments might be needed.
Proteasome inhibitors - These types of medications help destroy unnecessary proteins that are created by myeloma cells and also kills the cells in the process.
While often overlooked, self-care can help ease multiple myeloma symptoms and should be part of a comprehensive treatment plan. Practicing self-care doesn't mean completely overhauling your life. In fact, small changes can significantly improve how you feel. Here are a few tips to help get you started:
Although self-care alone doesn't necessarily drive multiple myeloma into remission, it can help ease symptoms and can improve your overall quality of life.
Indeed, multiple myeloma is a life-altering disease, but it doesn't have to signify the end of your life. There are a variety of treatments that are effective in not only easing symptoms but also driving the disease into remission. Of course, the sooner you seek treatment, the better off you will be in the long run.